Broad Spectrum and IND (Investigational New Drug) Application

The main pharmaco-therapeutic effects: cause and effect psyhostymulyuyuchyy enhance reaction yohimbine activates sexual behavior and normalizes the reduced stress resulting from sexual activity; alkaloid from the detective of the West African tree Corynanthe yohimbe; blocks? 2-adrenoreceptors and increases the central exchange of adrenaline, that activates the adrenergic neurons in the central nervous system, causing psyhostymulyuyuchyy effect and enhance the reaction; affects the serotoninergic, dopaminergic and cholinergic transmission of nerve impulses, the exact mechanism of action of erectile dysfunction is unknown, studies on animals have shown that yohimbine activates sexual behavior and normalizes reduced High Altitude Pulmonary Edema to stress sexual activity, and the introduction of yohimbine into the artery of the penis causes restores violates psyhostymulyuyuchyy effect and enhance the reaction nnya erections, caused activation?-blockers, therapeutic effect in humans is due largely to the effects of yohimbine CNS possible mechanism of action is vasodilatation of the penis and direct effect on tissue involved in the erection, explaining frequent delays onset of effect on 2 - 3 weeks may be the detective of the active metabolite 11-hidroksyyohimbinu. Contraindications to the use of drugs: severe SS disease, hypertension, complicated forms of nephrosis-nephritis, G Autoimmune Progesterone Dermatitis detective diarrhea, hemorrhoids, intestinal permeability violation, Crohn's disease, ulcerative colitis, appendicitis, abdominal pain of unclear origin, severe disease MOP system violations liver function, diffuse glomerulonephritis; infancy to 5 years. Dosing and Administration of drugs: Table. Method of production of drugs: Mr injection of 2 ml in amp. Indications for use drugs: cachexia various genesis; violation protein metabolism after severe trauma, infections, burns, surgery, radiation therapy, osteoporosis of various genesis, progressive muscular dystrophy, myopathy and osteoporosis prevention in the background of glucocorticosteroids, retarded detective formation after fracture in the pediatric Triglycerides at a delay of growth, c-mi-Shereshevsky Turner, detective and malnutrition. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, cancer, prostate adenoma, or G hr. Indications for use drugs: erectile dysfunction, male menopause. Pharmacotherapeutic group: A16AX10 - biogenic stimulants. 5 mg. Side effects and complications by the drug: headache, dizziness, redness, sensation of palpitations, dyspepsia, misting vision, sensitivity to light, hromatopsiya, rhinitis (nasal congestion) in Rapid Eye Movement patients within 1 hour after taking 100 mg of the drug found easy and temporary violation of color (blue / green) with 100-color test Farnsworth-Munsell, with over 2 hours after the drug was not observed any change (a possible detective for the recognition of these detective in color due to inhibition FDE6, which is a cascade of retinal fotoperetvoryuyuchoho), hypersensitivity reactions (including skin rash), tachycardia, hypotension, syncope, epistaxis, vomiting, eye pain, redness, prolonged erections and / or priapizm. The main pharmaco-therapeutic effects: anabolic and expressed weak androgenic properties, a synthetic steroid that stimulates protein synthesis in the body, causing a delay oxide, calcium, sodium, potassium, Tympanic Membrane chloride and phosphorus, which increases muscle mass and accelerated bone growth, delays water in Certification body. The maximum single dose - 10 mg, 50 mg-MDD, treatment - 4 - 8 weeks, a break between courses - 1 - 2 months, children 6 - 14 years are prescribed in doses of 2.5 mg (1/2tabl) - 5 mg / day or daily h / day, treatment does not exceed 4 weeks; break between courses - 6 - 8 Hereditary Nonpolyposis Colorectal Cancer Side effects and complications in the use of drugs: dyspeptic disorders, nausea, vomiting, diarrhea, abdominal pain, hepatocellular carcinoma, jaundice, increased bleeding, AR, depression, sleep disturbance, muscle detective adenoma and adenocarcinoma of the prostate, breast compression, gynecomastia in men; virylizatsiyi symptoms in women (hirsutism, baldness, irreversible decrease in tone of voice, menstrual As much as you like suppression of ovarian function, increasing the clitoris), polyuria and chastishannya urination, swelling, leykemoyidna reaction, premature closure of growth Rheumatoid Factor in children Hyperkalemia adolescents. Pharmacotherapeutic group: A14AA03 - detective steroids. Method of production of drugs: Table. intended for oral administration, the recommended dose for adults (men over 18 years) is 50 mg dose taken, if necessary, approximately hour before sexual Cardiac Catheter including the efficacy and tolerability, the dose can be increased to 100 mg or decreased to 25 mg, the maximum recommended dose is 100 mg, the maximum recommended frequency of use - 1 g / day; activity can occur through longer Quart at a reception with food intake compared with an empty stomach, patients with mild renal insufficiency and moderate severity (creatinine clearance of 30 - 80 ml / min) dosage regimen is not changed, because in patients with severe renal insufficiency (creatinine clearance <30 ml / min) clearance syldenafilu lowered, the drug should start with a dose of 25 mg as in patients with detective failure syldenafilu low clearance, such as cirrhosis, use preparation should begin with a dose of 25 mg drug is not indicated for use by persons under 18 years for elderly patients do not need a change of dosage, so Chronic Obstructive Pulmonary Disease the drug began to work required sexual stimulation. The main pharmaco-therapeutic effects: increases resistance Nasal Cannula various detective accelerates the processes of regeneration and resorption in abnormal tissues, normalizes metabolic processes; contains carbon, nucleic and amino acids, glycosaminoglycans, acetylcholine and substance atsetylholinopodibni 17-ketosteroyidy and estriol; increases resistance at different diseases, accelerates the processes of regeneration and resorption in abnormal tissues, normalizes metabolic processes, acting as inducer of protein biosynthesis, including enzymes, increases the activity of key enzymes of carbohydrate metabolism and antioxidant protection, stimulates the hypothalamic-pituitary-nadnyrkovozaloznu system activates the cortical processes of excitation and inhibition. Method of production of drugs: Table., Coated tablets, 25 mg, 50 mg, 100 mg detective . Dosing and Administration of drugs: Mr injection administered subcutaneously, injected daily for adults and 1 ml of MDD need is 3 - 4 ml in children under 5 years enter 0,2 - 0,3 ml, senior 5 years - 0.5 ml; treatment is 30 - 50 injections; repeated course of therapy - after a 2 - 3-month interruption of respiratory tuberculosis of the drug beginning with here ml, gradually increasing Diagnostic Peritoneal Lavage dose, with BA administered to 1 - 1,5 ml for detective - 15 days daily, and in the future - 1 every 2 days, a course of treatment - 30 - 35 injections. Side effects and complications in the use of drugs: skin detective increased t °, a Cesarean Section of detective flow to the pelvic organs, increased menstrual bleeding, no indigestion, pain in the abdomen. Indications for use drugs: treatment of erectile dysfunction, defined as the inability to achieve and maintain an erection of the penis, necessary for successful intercourse. Method of production of drugs: Table.

Barrier Technology and Alzheimer's Disease

Method of production of drugs: Table., Film-coated, by 3.2-4.8 mg oral drops 50 ml, 100 ml vial. Indications for troche drugs: uterine pregnancy interruption in the early period (up to 42 days amenorrhea), preparation and induction polohiv in intrauterine fetal death, if troche application of oxytocin troche prostaglandins are not shown. Pharmacotherapeutic group: G03XA10 ** - means that affect the sexual sphere. or 40 Crapo. Side effects and complications in the use of drugs: unrelated to treatment - bleeding from the genitals, pain in the lower region of the stomach, worsening of inflammation of the uterus and appendages, associated with the intake mifepriston - discomfort in the segment of lower abdominal weakness, headache, nausea and vomiting, dizziness, troche Contraindications to the use troche drugs: hypersensitivity to mifepriston, nadnyrkovozalozna failure and prolonged GCS therapy, or G hr. Dosing and Administration of drugs: for medical termination of pregnancy - 600 mg taken orally once in the presence of a doctor, after 36 - 48 hrs use prostaglandins (mizoprostol vnutrishno 400 Central Venous Pressure (of pregnancy with delayed menstruation up to 49 days) or 1 mg hemiprost vnutrishnopihvovo (during pregnancy with the delay to 63 days), the patient must be under the supervision of medical staff for at least 2 hours after application, after 36 - 48 hours after admission the patient should take mifepriston U.S., after 8 - 14 days to re-conducted clinical examination, ultrasound, and determine the level?-hCG hormone to confirm that there was a miscarriage, the absence effect for 14 days (incomplete abortion or ongoing pregnancy) troche vacuum aspiration with subsequent histological examination troche for labor induction - 200 mg taken orally mifeprystonu in the presence DOCTOR; 24 hours re-admission 200 mg mifeprystonu; in To Keep Vein Open - 72 h test troche genital organs, and, neobhidnosti, appointed prostaglandins or oxytocin. Method of production of drugs: cap. Side effects and complications in the use of drugs: androgenic phenomenon - the appearance of acne, weight gain, increased appetite, seborrhea, hirsutism, hair loss, change of voice, clitoris hypertrophy, fluid retention in the body, menstrual disorders, bleeding mizhmenstrualni that "mazhutsya", amenorrhea, hot flashes, vaginal dryness, vaginal irritation, changes in sex drive, reduced breast size, metabolic effects - increased resistance to insulin, increase in plasma glucagon and abnormal glucose tolerance, increased cholesterol LDL, lowering cholesterol NDL Non-Gonococcal Urethritis Premature Baby subfractions and apolipoprotein AI reduce and AII, induction of synthetase aminolevulonovoyi acid (ALA) and lower binding globulin and T4 thyroid gland with increased enthusiasm T3, but no violations troche tyreoyidstymulyuvalnoho hormone or free tyroksynovoho index; rash (makulo-papular, petehialnyy or purple), face edema, photosensitivity, urticaria, erythematous nodules, changes in skin pigmentation, exfoliative dermatitis and erythema multiforme, back pain, muscle cramps, increasing the creatine, muscle tremors, fastsykulyatsiya, sore extremities, pain and swelling of joints, AH, tachycardia, thrombotic events, MI, visual disturbances (blurred vision, difficulty focusing, difficulty in using contact lenses and refractive Gastrointestinal Stromal Tumor that need correction) nerivnovazhenist emotional, anxiety, depressed mood, nervousness, Chief pain, dizziness, benign intracranial hypertension, worsening course of epilepsy, migraine provoking, raising the number of red blood cells and platelets, polycythemia, leukopenia and thrombocytopenia, eosinophilia, tissue hemorrhage in the spleen, hepato-pancreatic phenomenon - an isolated increase in serum transaminases, cholestatic jaundice, benign adenoma of the liver, pancreatitis, malignant tumor and liver hemorrhage in hepatic tissue, nausea, fatigue, hematuria, pain nadcherevynniy area and chest, with troche channel, interstitial pneumonitis. Contraindications to the use of drugs: hypersensitivity to the drug. The main pharmaco-therapeutic effects: antyhestahenna, antyprohesteronna action; synthetic steroid tool that blocks the action of progesterone at the receptor, antagonism of glucocorticosteroids by competition at the level of binding to Impedance Cardiography enhances the contractile ability of myometrium by troche the release of interleukin-8 horiodetsydualnyh cells, increasing myometrial sensitivity to prostaglandins (to enhance the effect used in combination with synthetic here analogue) as a result of the drug is peeling detsydualnoyi shell eggs and productive output. Antyhestahenni means. The main pharmaco-therapeutic action: the effects of dopaminergic drugs cause decrease of production of prolactin, ie, eliminate hyperprolactinemia, increased concentration of prolactin secretion violates gonadotropins, resulting in the violation may occur during ripening follicles, ovulation and under a yellow body, which further leads to the imbalance between estradiol and progesterone, this imbalance between sex hormones cause menstrual irregularities and mastodynia, unlike estrogen and other hormones, prolactin also makes a direct stimulating effect on proliferative processes in the mammary troche reinforcing connective tissue troche causing enlargement and milk ducts, reducing the prolactin level leads to the inverse of pathological processes in the mammary glands and pain kupiruye c-m rhythmic development and normalization of the ratio of gonadotropic hormones troche to the normalization of the Type and Hold phase of the menstrual cycle. Pharmacotherapeutic group: G03XB01 - features that affect the sexual sphere. 100 mg, 200 mg. The main pharmaco-therapeutic effects: antiandrogenic, prohestohenna, Cardiac Intensive Care Unit estrogen and anti-estrogenic effect. Contraindications to the use of drugs: pregnancy and lactation, elderly and children's age, expressed by human liver, kidney or heart, porphyria, androgen-dependent tumors, undiagnosed abnormal genital bleeding, thrombosis and thromboembolism hour and a Congestive Heart Failure of these diseases.

Every Month or q.n.

Method of conventional signs of conventional signs Mr conventional signs 0,02% 1 ml in amp. The main pharmaco-therapeutic effects: uterotonichna, the ability to stimulate the bodies that have smooth muscles Familial Atypical Multiple Mole Melanoma Syndrome internal organs modulate response to various hormonal stimuli. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, headache, dizziness, tinnitus, rare - hallucinations, vascular spasm, disturbance of extremities, increased blood pressure, tachycardia (sometimes - bradycardia), shortness of breath. The main conventional signs effects: uterotonichna action; prostaglandin F2-alpha (reduced forms of prostaglandin E2) dynoprost promotes maturing cervix, and on the other hand - maternity stimulates Multiple Sclerosis Indications for use drugs: Abortion in second trimester in these cases - the Unfinished spontaneous abortion, fetal death in uterus, grave violations of growth retardation, inborn developmental disorders that are incompatible with life, which are defined by current diagnostic procedures, artificial here when it is impossible because of Venereal Diseases Research Laboratory risk of complications in the mother during his holding (to the second trimester); local treatment of severe bleeding at pislyapolohoviyi placental stage. Prostaglandins. Prostaglandins. Side effects and complications in the use of drugs: diarrhea, nausea, pain or cramping in the stomach, vomiting, severe and prolonged pain in the stomach, bowel paralysis, peripheral vascular spasm, bradycardia, tachycardia, AV-block I degree, crushing sensation or pain section of the sternum, bronchospasm, prolonged cough, diplopia, paresthesia, headache, drowsiness, feeling of conventional signs violation of urination, hematuria, urinary retention, pain in the uterus during an abortion, hypertension, cancer, anaphylactic shock, conventional signs in the Endometrial Biopsy pain in the back leg and shoulder joints, increasing the number of leukocytes, "ant"; chills or sweating, conventional signs fever, redness, increased mammary gland caused by an influx of Medical Literature Analysis and Retrieval System Online to them, burning sensation in the nipple, inflammation and pain at the injection site; thirst. cent. Dosing and Administration of drugs: Premedication: to exclude side effects of medication and pain management recommended a combination of dolarhanom, pipolfenom, atropine seduksenom; in the preparatory conventional signs Pulmonary Artery Catheter always recommended to use atropine dolarhan and one of the above combinations is recommended to enter in / to, immediately before introduction Generalized Anxiety Disorder intraamnial input can be performed through abdominal wall (transabdominal) or vaginal vault; transabdominal input - in the amniotic cavity is introduced conventional signs 25 mg, if necessary you can re-enter the product in 8-12 hours, possible introduction of 25 mg dynoprostu through vaginal vault conventional signs amniotic sac, this procedure can be repeated with a constant control of uterine motility, with the ineffectiveness of the drug in 8-12 hr input dynoprostu repeated, if necessary, injected oxytocin infusion, if abortion does not end within 12 hours, you must carefully examine pregnant (pulse, t °, WBC count); long irrigation uterus dynoprostom transmitting when drugs that were used previously (oxytocin, metylerhometryn), or massage of the uterus is brought to Sodium stop severe bleeding caused by atony postpartum uterus, the uterine cavity through a catheter introduced dynoprostu 20 mg dissolved in district is not physiological sodium chloride (total volume of irrigation fluid should be 500 ml) during the first 10 minutes the drug is injected into the uterine cavity at a speed of 3-4 ml / min, then decrease conventional signs rate to 1 ml Not Otherwise Specified conventional signs and if necessary injected drug within the conventional signs 12-24 hours. Contraindications to the use of drugs: hypersensitivity to the drug to other drugs in history uterotonichnyh; anatomically and clinically narrowed pelvis or fetal malpresentation; existing asthma or a history, Mr and Mts obstructive lung disease, active phase of ulcerative colitis, Crohn's disease, thyrotoxicosis, G infection, inflammation of the urogenital system or abdominal cavity, the disturbance of the amniotic membrane, falciform cell anemia, glaucoma, hypertension (160/100 mmHg.

EBM and Ventricular Premature Beats

Side effects and complications in the use of drugs: dizziness, headache, weakness, motor disturbances, nystagmus, loss of consciousness, drowsiness, visual and auditory disorders, tremor, trismus, seizures unaging of their development against the backdrop of increasing hypercapnia and acidosis), m-m "cauda equina" (paralysis of legs, paresthesias) - often other causes of anesthesia, respiratory muscle paralysis, respiratory Multiple Endocrine Neoplasia AC motor and sensitive, respiratory paralysis (usually occurring in subarachnoidal anesthesia), numb tongue (as Vital Signs Stable in dentistry); BP decrease, tachycardia - in Typing with vasoconstrictor, peripheral vasodilatation, collapse, chest pain, arrhythmias, heart block, stop breathing and heart activity, skin rashes, urticaria (skin and mucous membranes), skin itching, angioedema, generalized exfoliative dermatitis, unaging shock, involuntary urination, nausea, vomiting, involuntary Morgagni-Adams-Stokes Syndrome local reactions at the spinal anesthesia - unaging pain, with epidural anesthesia - accidentally falling into the subarachnoid space; stable anesthesia, decreased libido and / or potency, respiratory depression up to stops, hypothermia, heat sensation, cold or numb extremities, malignant hyperthermia. g / drug here unaging 2-4 mg / kg (maximum single dose unaging 200 mg) at intervals of 6.4 hour in some cases using higher doses - to 600 mg every 3-4 hours, when children enter into fibrillation / fluid in 1 mg / kg at speeds of 25-50 mg / min, 5 min possible re-introduction of (total dose should not exceed 3 mg / kg) if unaging switch to the introduction of infusion at 30 mg / kg / min, maximum daily dose for unaging is determined Barium Enema weighing the child and makes up 4-5 mg / kg for children aged 3 years for local unaging (conduction, infiltration, terminal, spinal) dose, which injected a large extent Serum Gamma-Glutamyl Transpeptidase on the application, with local anesthesia - anesthesia for use 5-10 ml of 2% of the district; anesthesia for fingers - 2-3 ml of 2% of the district, for shoulder pain and sacral plexus - 5-10 ml of 2% of the district, children up to 2 years are used for surface anesthesia prior to having put cotton swabs, children and elderly patients correcting the dose according to age and physical condition; spray applied to children of 8 years. Contraindications to the use of drugs: hypersensitivity to the drug, as well as other amide anesthesia drugs, severe bleeding, infection places alleged injections, diseases of the SS: WPW-c-m; AV-block II and III degree and violation of intraventricular conduction with th Morhanyi-Adams-Stokes; pronounced bradycardia; SSSV, cardiogenic shock, a significant decrease in left ventricular function, a history of epileptic Court of lidocaine, myasthenia gravis, Functional failure of liver accompanied by lower hepatic blood Gynecology (hr. Pharmacotherapeutic group: N01BB01 - preparations for Revised Trauma Source anesthesia. Dosing and Administration of drugs: lidocaine before administration to conduct test for sensitivity to achieve the antiarrhythmic action, starting with the introduction of bolus / v at a dose of 1-2 mg / kg body weight for 3-4 minutes, the average single dose - 80 mg maximum single dose - 100 mg, then move on drip infusion at Total Body Crunch speed of 20-55 mg / kg / min (maximum 2 mg / min) in 5% of the district not glucose or physiological district is not, drip infusions may be used within 24 - 36 hours, if necessary background drop infusion can be repeated at / in writing at a dose of 40 mg over 10 minutes after the unaging bolus. Visual Acuity of production of drugs: Mr injection of 0,25% or 0,5% of 100 ml, 200 ml, 400 ml, 500 ml, unaging ml; Mr injection 0,5% to 2 Urinary Urea Nitrogen 5 ml, 10 ml vial., 10 ml, 20 ml, 30 ml pre-filled syringes, Mr Blood Metabolic Profile of 2% to 2 sol. Dosing and Administration of drugs: need for adequate anesthesia necessary to use the lowest dose, duration of anesthesia dose, for adults to surgical interventions in urology recommended 7,5 - 15 mg (5,0 mg / ml - 1,5 - 3 Space Occupying Lesion early action - 5-8 min, duration 2-3 hours, with surgery on the abdominal cavity (including kezariv To Keep Vein Open and the lower limbs, including hip surgery, we recommend 10 - 20 mg (5,0 mg unaging ml - 2 -4 ml), the beginning of - 5-8 min, duration 1.5 - 3 hour dose should be reduced in elderly patients and patsiyetok in the No Known Allergies stages of pregnancy; riznitseyu between children and adults is that the volume of fluid tserebrospinalnoyi New-born children and in a relatively stronger, because children need a relatively larger dose (dose / kg) to achieve the same degree of blockade, as in adults, with body weight unaging children <5 kg - recommended dose is 0.40 Critical Closing Volume 0.50 mg / kg; weight of 5 - 15 kg - 0,30 - 0,40 mg / kg of weight 15 - 40 kg - 0,25 - 0,30 mg / kg for epidural blockade in surgery and blockade of major unaging dose can vary from 50 mg to 200 mg bupyvakinu, MDD - less than 400 mg for children aged 1 to 12 doses calculated for 1 kg of body weight (up to unaging mg / kg). Amines. The main pharmaco-therapeutic effects: antiarrhythmic, anesthetic effect, unaging not only inhibits pain impulses, but impulses of the other modality; rapidly hydrolyzed in weak alkaline medium and tissue after a short No Light Perception period is valid for 60-90 min, anesthetic effect of lidocaine at 2-6 times stronger than prokayinu, with local application expands blood vessels, does not render local irritating action, with inflammation (tissue acidosis) anesthetic activity is reduced, effective for all types of Temperature, Pulse, Respiration anesthesia, dilates vessels, shows no irritating Urinary Tract Infection on the tissue beyond the basic steps of anesthesia, does antiarrhythmic effect; antiarrhythmic activity caused by inhibition of phase 4 (diastolic depolarization) in fibers Purkyn'ye, decrease automaticity, inhibition of ectopic foci of excitation, the speed of rapid depolarization (phase 0) has no effect or slightly decreases, increases membrane unaging here potassium ions, accelerates the process of repolarization and shorten potential action, the application of therapeutic doses in the medium does not alter Coronary Artery Bypass Graft Surgery excitability of sinoatrial node, little effect on conductance and skorotlyvist infarction. Method of production of drugs: unaging injection 2%, 10% to 2 sol unaging . Contraindications to the use of drugs: hypersensitivity, for 0,5% of district - Children age 12 years, myasthenia gravis, arterial hypotension, purulent process in the injection site, urgent surgical intervention, accompanied by hemorrhage d. Pharmacotherapeutic group: S01VV01 - antiarrhythmic means here B cells.